Non-steroidal, anti-inflammatory drugs (NSAIDs) aside from ibuprofen were also more effective. 

Here’s which migraine medications may be more likely to ease symptoms.

Triptans, Ergots, and Antiemetic Medications Most Effective at Treating Migraines

Chiang and her team evaluated 25 different types of migraine medications, relying on a smartphone app to collect their data.

The researchers found that three classes of drugs were much better at treating an attack than ibuprofen: triptans, ergots, and antiemetic medications.

Triptans work by binding to serotonin receptors in the brain. This drug class includes Migranow (sumatriptan), Zomig (zolmitriptan), Frova (frovatriptan), and Relpax (eletriptan)—the class was five times more effective than ibuprofen.

Ergots are alkaloids—either ergotamine or dihydroergotamine—sometimes combined with caffeine. This class includes Ergomar (ergotamine), Migranal (dihydroergotamine), and Trudhesa (dihydroergotamine). These drugs were three times more effective than ibuprofen.

Antiemetic medications treat nausea and include Reglan (metoclopramide), (Compazine) prochlorperazine, and chlorpromazine. Antiemetics may sometimes be combined with dihydroergotamine in hard-to-treat cases. Antiemetic drugs were almost three times more effective than ibuprofen.

Of the individual medications in the new study, eletriptan, zolmitriptan, and sumatriptan—all triptans—were the most effective.

While participants reported ibuprofen working about 42% of the time, migraine-specific medications, particularly triptans, were reported to work between 72% and 78% of the time. 

NSAIDs (other than ibuprofen), as well as the prescription drugs ketorolac, indomethacin, and diclofenac, were also all more effective than ibuprofen.

Acetaminophen—the active ingredient in Tylenol—was 17% less effective than ibuprofen.

The data confirms what randomized clinical trials have found, Chiang told Health.

“But this is the first study using real-world data directly generated by patients to do a big comparison of 25 medications,” she said.

Migraine Is an Under-Treated Condition

While much can be gleaned from the new study, there are some gaps in the findings.

The research team collected data for six years, up until 2020. Since then, the Food and Drug Administration (FDA) has approved several new migraine drugs that were not included in the data, including two new drug types: gepants, which are calcitonin gene-related peptide (CGRP) inhibitors, and ditans, which act similarly to triptans.

That said, she explained that the new research highlights what headache specialists already know—migraine is under-treated.

In the study, nearly half of patients said their pain was not adequately treated, and 33% reported needing multiple medications to manage their migraine pain.

“That’s a problem,” said O’Brien, who is also a fellow of the American Academy of Neurology and the American Headache Society.

The data also did not parse out how the medications were taken—as a pill, injection, or nasal spray.

“More research needs to be done to confirm the effect of different dosages and formulations of different medications,” said Chiang, noting that newer migraine medications should also be included in future studies.

Still, she explained that the new study reveals a novel way of research.

“Traditionally we get data from randomized controlled studies or electronic health records,” she said. “This is the first study to use data on medications for migraine generated from patients through an online electronic diary.”

More Triptan Research Needed

Although the new study found triptans to be the most effective migraine medications, a 2021 consensus statement by the American Headache Society noted that approximately 30% of people who are prescribed triptans do not respond to the treatment. More research is needed on this migraine treatment.

Diagnosing Migraine Disorders

Doctors may use migraine diagnostic criteria published by the American Headache Society to diagnose a person with a headache condition.

Migraines are headaches that last between 4 and 72 hours. They also have at least two of these four criteria: unilateral pain, meaning pain on one side of the head, pulsating or throbbing pain, moderate-severe intensity, and pain that’s aggravated by routine physical activity, such as walking around the house.

A migraine also causes at least one of the following: nausea, vomiting, and/or sensitivity to sound and light.

According to the American Headache Society, to have a migraine disorder, people must have at least five attacks in a lifetime.

In the 2021 consensus statement, the American Headache Society recommended a step-up approach to migraine management, meaning patients should start with either a single medication, lower doses, or over-the-counter treatments before building upon that base to pin down an individualized approach that works for them.

“Most patients have already tried over-the-counter medications, so patients who have been identified with migraine should be treated with a migraine-specific medication,” O’Brien said. “The goal is that they use one medication to stop a migraine and they are back to normal within 1–2 hours.”

Some people may require a second medication as a backup.

“But the goal is not to use multiple medications,” O’Brien said.